Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 699)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0305498	0.1095947	0.7831616
Weighted median	23	0.0171880	0.0575567	0.7652240
Inverse variance weighted	23	0.0148632	0.0418754	0.7226359
Simple mode	23	0.0780631	0.0951944	0.4209904
Weighted mode	23	-0.0058870	0.0659659	0.9296958

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.31431	21	0.2338077
Inverse variance weighted	25.34346	22	0.2809336

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009633	0.0061948	0.87791

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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