Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 698)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0755925	0.0998206	0.4572938
Weighted median	23	0.0711286	0.0557490	0.2020011
Inverse variance weighted	23	0.0329428	0.0390156	0.3984736
Simple mode	23	0.0843507	0.0991659	0.4041537
Weighted mode	23	0.0702283	0.0738697	0.3520829

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.36065	21	0.8536151
Inverse variance weighted	14.57612	22	0.8797779

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026191	0.0056424	0.6472888

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004633	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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