Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 697)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0167099	0.0998208	0.8686578
Weighted median	23	0.0744690	0.0547097	0.1734614
Inverse variance weighted	23	0.0618227	0.0390158	0.1130670
Simple mode	23	0.0480063	0.0773147	0.5410325
Weighted mode	23	0.0531656	0.0640257	0.4152450

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.380773	21	0.9858877
Inverse variance weighted	9.621850	22	0.9894213

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027704	0.0056424	0.6285209

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003677	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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