Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 696)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0840560	0.1141767	0.4697583
Weighted median	23	0.0427113	0.0656480	0.5152981
Inverse variance weighted	23	0.0025997	0.0442203	0.9531187
Simple mode	23	-0.1043682	0.1498414	0.4933947
Weighted mode	23	0.1291895	0.1003706	0.2114288

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.47607	21	0.1556454
Inverse variance weighted	28.26208	22	0.1671575

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050023	0.0064539	0.4469328

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008565	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8