Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 695)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0704701	0.1053852	0.5109771
Weighted median	23	-0.0043476	0.0613006	0.9434598
Inverse variance weighted	23	-0.0223787	0.0404784	0.5803631
Simple mode	23	-0.0592526	0.1020085	0.5672389
Weighted mode	23	-0.0073081	0.0771064	0.9253484

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.40691	21	0.3226725
Inverse variance weighted	23.68088	22	0.3641769

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029533	0.0059569	0.6251996

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007276	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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