Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 694)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0465481	0.0998205	0.6457889
Weighted median	23	0.0528703	0.0527568	0.3162707
Inverse variance weighted	23	0.0264934	0.0390157	0.4971099
Simple mode	23	0.0934107	0.0953946	0.3381253
Weighted mode	23	0.0650411	0.0694058	0.3588745

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.34001	21	0.8962482
Inverse variance weighted	13.38766	22	0.9217827

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012316	0.0056424	0.8293249

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004197	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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