Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 693)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0558802	0.1283883	0.6678261
Weighted median	23	0.0085461	0.0564020	0.8795651
Inverse variance weighted	23	-0.0268645	0.0495965	0.5880525
Simple mode	23	0.0040897	0.0859043	0.9624588
Weighted mode	23	0.0113018	0.0546924	0.8381895

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.73978	21	0.0301477
Inverse variance weighted	35.55081	22	0.0339046

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050813	0.0072571	0.4914961

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010916	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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