Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 692)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2027569	0.0998187	0.0550781
Weighted median	23	-0.0486727	0.0572530	0.3952504
Inverse variance weighted	23	-0.0872151	0.0390148	0.0253887
Simple mode	23	0.0267852	0.1084817	0.8072679
Weighted mode	23	-0.0276563	0.0851816	0.7484947

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.55748	21	0.7375567
Inverse variance weighted	18.13892	22	0.6977208

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070955	0.0056423	0.2223592

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000701	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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