Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 691)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0469234	0.0999239	0.6434863
Weighted median	23	0.0289431	0.0550362	0.5989631
Inverse variance weighted	23	-0.0028466	0.0390157	0.9418374
Simple mode	23	0.0907583	0.1000783	0.3743006
Weighted mode	23	0.0521700	0.0600217	0.3941297

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.04351	21	0.4562895
Inverse variance weighted	21.33694	22	0.5000065

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030564	0.0056482	0.5941157

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006467	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8