Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 690)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0438242 0.1041442 0.6781743
Weighted median 23 -0.0029503 0.0577746 0.9592735
Inverse variance weighted 23 -0.0364018 0.0404275 0.3678959
Simple mode 23 0.0743442 0.0934965 0.4350187
Weighted mode 23 0.0210858 0.0751077 0.7815328

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 22.85895 21 0.3515449
Inverse variance weighted 23.62137 22 0.3673845

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0049267 0.0058867 0.4120657

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007422 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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