Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 69)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0423941	0.1131326	0.7116195
Weighted median	23	0.0642207	0.0611719	0.2937918
Inverse variance weighted	23	-0.0026973	0.0433949	0.9504369
Simple mode	23	0.0819962	0.1158188	0.4863977
Weighted mode	23	0.0691035	0.1014954	0.5030677

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.97574	21	0.1716576
Inverse variance weighted	27.21660	22	0.2031150

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027691	0.0063949	0.6694166

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008249	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

Funnel plot

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Leave-one-out sensitivity analysis

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