Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 689)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0117141	0.1037325	0.9111619
Weighted median	23	0.0073182	0.0562012	0.8963964
Inverse variance weighted	23	-0.0044495	0.0396181	0.9105782
Simple mode	23	-0.0026188	0.0808775	0.9744612
Weighted mode	23	0.0034739	0.0638476	0.9571007

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.67834	21	0.3613655
Inverse variance weighted	22.68459	22	0.4197187

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004461	0.0058635	0.9400721

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006878	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8