Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 688)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0739381	0.0998203	0.4670706
Weighted median	23	0.0554003	0.0558088	0.3208664
Inverse variance weighted	23	0.0383558	0.0390155	0.3255623
Simple mode	23	0.0404552	0.0931258	0.6682187
Weighted mode	23	0.0775327	0.0757772	0.3173491

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.74220	21	0.9463174
Inverse variance weighted	11.89218	22	0.9595659

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021851	0.0056423	0.7024534

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003897	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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