Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 687)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0065490	0.0998208	0.9483111
Weighted median	23	0.0142273	0.0534838	0.7902301
Inverse variance weighted	23	0.0315548	0.0390159	0.4186490
Simple mode	23	0.0250648	0.0819228	0.7625147
Weighted mode	23	0.0025715	0.0584709	0.9653182

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.45639	21	0.6830975
Inverse variance weighted	17.53046	22	0.7334363

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015356	0.0056423	0.7881588

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000551	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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