Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 686)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0677440	0.1014344	0.5114965
Weighted median	23	0.0868997	0.0608301	0.1531296
Inverse variance weighted	23	0.0690542	0.0390151	0.0767378
Simple mode	23	0.1290758	0.1009491	0.2143543
Weighted mode	23	0.1376245	0.0786746	0.0941808

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.68496	21	0.4178551
Inverse variance weighted	21.68516	22	0.4788097

Test for directional horizontal pleiotropy

egger_intercept	se	pval
8.05e-05	0.0057336	0.9889364

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000752	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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