Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 685)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1642388	0.1153748	0.1692729
Weighted median	23	-0.0069365	0.0576729	0.9042668
Inverse variance weighted	23	-0.0382156	0.0455118	0.4010845
Simple mode	23	0.0332602	0.0873375	0.7069863
Weighted mode	23	0.0012949	0.0584099	0.9825125

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.05503	21	0.1385975
Inverse variance weighted	29.93638	22	0.1200190

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077391	0.0065216	0.2486

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009361	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8