Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 684)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0293958	0.0998208	0.7712783
Weighted median	23	-0.0396836	0.0553500	0.4733995
Inverse variance weighted	23	-0.0131461	0.0390159	0.7361615
Simple mode	23	-0.1387609	0.0918078	0.1449114
Weighted mode	23	-0.0548332	0.0615909	0.3829485

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.12410	21	0.7626385
Inverse variance weighted	16.15538	22	0.8081002

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009979	0.0056424	0.8613147

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000493	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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