Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 683)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0671015	0.1076321	0.5397127
Weighted median	23	0.0431625	0.0559379	0.4403425
Inverse variance weighted	23	-0.0086899	0.0416706	0.8348095
Simple mode	23	0.0452157	0.0961362	0.6427487
Weighted mode	23	0.0383188	0.0625797	0.5466036

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.41555	21	0.2733627
Inverse variance weighted	25.09601	22	0.2925056

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046543	0.0060839	0.4527673

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000762	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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