Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 682)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1721178	0.0998198	0.0993474
Weighted median	23	0.0401911	0.0560281	0.4731656
Inverse variance weighted	23	-0.0120634	0.0390154	0.7571729
Simple mode	23	0.0470653	0.1099163	0.6726741
Weighted mode	23	0.1052981	0.0777205	0.1892217

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.67204	21	0.7877857
Inverse variance weighted	19.69046	22	0.6023952

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0113106	0.0056423	0.0580693

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005996	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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