Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 681)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1003683	0.1204724	0.4141508
Weighted median	23	0.0713171	0.0570714	0.2114419
Inverse variance weighted	23	0.0311530	0.0464294	0.5022351
Simple mode	23	0.0628790	0.1133018	0.5845147
Weighted mode	23	0.0693007	0.0804970	0.3985728

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.58903	21	0.0807749
Inverse variance weighted	31.15654	22	0.0929565

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042505	0.0068097	0.5392287

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009633	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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