Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 680)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0923727	0.1332938	0.4959023
Weighted median	23	-0.0308939	0.0582089	0.5955974
Inverse variance weighted	23	0.0396972	0.0511248	0.4374679
Simple mode	23	-0.0624098	0.1198620	0.6077908
Weighted mode	23	-0.0660259	0.0751678	0.3892304

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.44758	21	0.0149476
Inverse variance weighted	37.77628	22	0.0194092

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032348	0.0075344	0.6720497

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001176	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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