Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 68)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1013186	0.1079249	0.3585128
Weighted median	23	0.0105095	0.0548193	0.8479675
Inverse variance weighted	23	0.0267750	0.0428139	0.5317206
Simple mode	23	-0.0401245	0.0881465	0.6534241
Weighted mode	23	-0.0245050	0.0590010	0.6819219

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.54841	21	0.2672518
Inverse variance weighted	26.49205	22	0.2311565

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078662	0.0061004	0.2112627

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000817	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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