Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 679)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0802483	0.0998206	0.4304475
Weighted median	23	-0.0400031	0.0550422	0.4673663
Inverse variance weighted	23	-0.0302460	0.0390156	0.4382050
Simple mode	23	-0.1136389	0.0898013	0.2189497
Weighted mode	23	-0.0580556	0.0612775	0.3537155

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.60300	21	0.5465173
Inverse variance weighted	19.89916	22	0.5893473

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030706	0.0056423	0.5920272

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006212	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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