Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 678)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0187711	0.0998192	0.8526422
Weighted median	23	-0.0379409	0.0575602	0.5097987
Inverse variance weighted	23	-0.0170646	0.0390155	0.6618359
Simple mode	23	-0.0649067	0.1057456	0.5456419
Weighted mode	23	-0.0649067	0.0948837	0.5010763

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.65803	21	0.7885469
Inverse variance weighted	15.65837	22	0.8324715

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001048	0.0056423	0.9853571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004803	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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