Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 677)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1041942	0.1308698	0.4348435
Weighted median	23	0.0816134	0.0619056	0.1873852
Inverse variance weighted	23	0.0634508	0.0501119	0.2054480
Simple mode	23	0.0110426	0.1401172	0.9378962
Weighted mode	23	0.1586241	0.0867860	0.0811807

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.09855	21	0.0213144
Inverse variance weighted	36.29521	22	0.0282256

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025021	0.0073975	0.7385445

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011799	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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