Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 676)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1317382	0.0998181	0.2011147
Weighted median	23	-0.0743647	0.0576967	0.1974364
Inverse variance weighted	23	-0.0856012	0.0390153	0.0282322
Simple mode	23	0.0316576	0.1000731	0.7547230
Weighted mode	23	0.0248969	0.0905739	0.7859736

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.71233	21	0.785590
Inverse variance weighted	15.96449	22	0.817644

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028333	0.0056423	0.6207807

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006296	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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