Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 675)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2445828	0.0998192	0.0231267
Weighted median	23	0.1222192	0.0550294	0.0263524
Inverse variance weighted	23	0.0434600	0.0395517	0.2718479
Simple mode	23	0.0597160	0.1044995	0.5734886
Weighted mode	23	0.1213770	0.0621721	0.0637472

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.81754	21	0.6605197
Inverse variance weighted	22.60928	22	0.4240654

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.012351	0.0056423	0.0400348

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007227	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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