Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 673)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1454858	0.0998207	0.1597792
Weighted median	23	-0.0996694	0.0546143	0.0680055
Inverse variance weighted	23	-0.0968314	0.0390157	0.0130698
Simple mode	23	-0.0599002	0.0808027	0.4663426
Weighted mode	23	-0.0966647	0.0650824	0.1516628

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.52866	21	0.7392517
Inverse variance weighted	16.80907	22	0.7738097

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029879	0.0056424	0.6019837

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000696	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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