Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 672)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1680978	0.1124116	0.1496932
Weighted median	23	0.0981827	0.0570265	0.0851231
Inverse variance weighted	23	0.0633079	0.0439627	0.1498568
Simple mode	23	0.1722251	0.1071393	0.1222058
Weighted mode	23	0.1125274	0.0662162	0.1033433

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.63249	21	0.1833513
Inverse variance weighted	27.93328	22	0.1779029

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064352	0.0063541	0.3227011

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009262	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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