Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 671)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1016531	0.0998210	0.3200994
Weighted median	23	-0.0709550	0.0558443	0.2038762
Inverse variance weighted	23	-0.0757083	0.0390155	0.0523230
Simple mode	23	-0.0937302	0.0888680	0.3030027
Weighted mode	23	-0.0834156	0.0595115	0.1749646

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.34177	21	0.8054206
Inverse variance weighted	15.42150	22	0.8435233

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015933	0.0056424	0.78042

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005814	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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