Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 670)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0013292	0.0998209	0.9895017
Weighted median	23	-0.0426990	0.0582811	0.4637790
Inverse variance weighted	23	-0.0399926	0.0390156	0.3053437
Simple mode	23	-0.0829551	0.0851800	0.3407036
Weighted mode	23	-0.0670123	0.0666234	0.3254297

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.71879	21	0.8367932
Inverse variance weighted	14.92105	22	0.8656038

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025376	0.0056424	0.657509

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000484	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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