Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 67)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0901379	0.0998204	0.3767673
Weighted median	23	0.0378316	0.0541893	0.4850912
Inverse variance weighted	23	-0.0160092	0.0390158	0.6815665
Simple mode	23	0.0682866	0.0968407	0.4881197
Weighted mode	23	0.0555288	0.0629901	0.3875512

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.16284	21	0.9351171
Inverse variance weighted	13.49752	22	0.9183507

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065185	0.0056423	0.2609507

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004141	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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