Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 669)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0800565	0.1024751	0.4433871
Weighted median	23	-0.0388776	0.0623808	0.5331337
Inverse variance weighted	23	-0.0211222	0.0394943	0.5927768
Simple mode	23	-0.0931599	0.1132535	0.4195746
Weighted mode	23	-0.0385310	0.0942921	0.6867586

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.13235	21	0.3919179
Inverse variance weighted	22.54379	22	0.4278605

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036192	0.0057924	0.5388257

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000692	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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