Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 668)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0643548	0.0998196	0.5260953
Weighted median	23	0.0039781	0.0573585	0.9447076
Inverse variance weighted	23	0.0156086	0.0390153	0.6891094
Simple mode	23	-0.0685337	0.1081076	0.5326566
Weighted mode	23	-0.0490692	0.0902035	0.5919240

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.74880	21	0.4743743
Inverse variance weighted	21.03028	22	0.5188677

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029935	0.0056423	0.6012985

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006421	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8