Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 667)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1011475	0.0998211	0.3224556
Weighted median	23	-0.0688329	0.0528483	0.1927586
Inverse variance weighted	23	0.0107028	0.0390157	0.7838387
Simple mode	23	-0.0214336	0.0759810	0.7805100
Weighted mode	23	-0.0673352	0.0613856	0.2845379

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.45474	21	0.5559934
Inverse variance weighted	20.93668	22	0.5246545

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068687	0.0056424	0.2369758

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006367	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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