Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 666)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0299095	0.1026740	0.7736756
Weighted median	23	0.0149281	0.0540126	0.7822549
Inverse variance weighted	23	0.0166207	0.0392266	0.6717767
Simple mode	23	-0.0089411	0.0865099	0.9186192
Weighted mode	23	0.0093555	0.0619922	0.8814187

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.21752	21	0.3870694
Inverse variance weighted	22.23844	22	0.4457363

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008161	0.0058036	0.8895162

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006794	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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