Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 665)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1132909	0.1063356	0.2987876
Weighted median	23	-0.0335340	0.0573469	0.5587110
Inverse variance weighted	23	0.0142835	0.0422176	0.7351149
Simple mode	23	-0.0203154	0.0965508	0.8352831
Weighted mode	23	-0.0578413	0.0723300	0.4324432

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.83143	21	0.3012977
Inverse variance weighted	25.75941	22	0.2621552

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078344	0.0060106	0.2065404

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007846	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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