Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 664)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1598375	0.1037066	0.1381916
Weighted median	23	-0.0234327	0.0575662	0.6839670
Inverse variance weighted	23	-0.0017334	0.0421100	0.9671647
Simple mode	23	-0.0387351	0.1025733	0.7093214
Weighted mode	23	-0.0418915	0.0635163	0.5163949

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.66722	21	0.3619750
Inverse variance weighted	25.62830	22	0.2679826

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0097091	0.005862	0.112531

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007767	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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