Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 663)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1613104	0.1012196	0.1259517
Weighted median	23	0.0298859	0.0546020	0.5841453
Inverse variance weighted	23	0.0172332	0.0407943	0.6727039
Simple mode	23	-0.0037212	0.0944337	0.9689224
Weighted mode	23	0.0624082	0.0652600	0.3493118

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.59280	21	0.4232912
Inverse variance weighted	24.05175	22	0.3445228

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0088478	0.0057214	0.1369394

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007347	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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