Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 662)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1354926	0.0998207	0.1890768
Weighted median	23	0.0176934	0.0550119	0.7477340
Inverse variance weighted	23	-0.0145618	0.0390158	0.7089779
Simple mode	23	-0.0850086	0.0948660	0.3799044
Weighted mode	23	-0.0042184	0.0659817	0.9496009

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.86303	21	0.8754102
Inverse variance weighted	16.53023	22	0.7887280

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092148	0.0056424	0.1173409

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005052	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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