Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 661)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0927326	0.1069971	0.3959104
Weighted median	23	0.0687240	0.0539018	0.2023142
Inverse variance weighted	23	0.0237693	0.0413333	0.5652486
Simple mode	23	0.1063091	0.0772424	0.1825758
Weighted mode	23	0.0767791	0.0569339	0.1911970

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.12813	21	0.2868919
Inverse variance weighted	24.69150	22	0.3120539

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004235	0.006048	0.4914645

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007595	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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