Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 66)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3098927	0.0998171	0.0053658
Weighted median	23	0.0757454	0.0600236	0.2069755
Inverse variance weighted	23	0.0666213	0.0390148	0.0877122
Simple mode	23	-0.1076569	0.1179519	0.3712850
Weighted mode	23	0.0685612	0.0903745	0.4561228

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.96130	21	0.8712558
Inverse variance weighted	20.97218	22	0.5224582

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0149396	0.0056422	0.0150496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007238	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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