Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 659)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1707165	0.0998189	0.1019526
Weighted median	23	0.0822167	0.0593658	0.1660779
Inverse variance weighted	23	0.0669226	0.0390154	0.0862922
Simple mode	23	0.1782568	0.1051816	0.1042328
Weighted mode	23	0.1694693	0.0782184	0.0413678

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.75254	21	0.5369804
Inverse variance weighted	21.02874	22	0.5189626

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006374	0.0056423	0.2713464

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007264	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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