Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 658)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1195971	0.0998201	0.2442156
Weighted median	23	0.0666524	0.0570831	0.2429531
Inverse variance weighted	23	0.0654076	0.0390155	0.0936498
Simple mode	23	0.1126200	0.1021122	0.2819878
Weighted mode	23	0.0836938	0.0668326	0.2236139

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.42375	21	0.6220533
Inverse variance weighted	18.77160	22	0.6593869

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033278	0.0056423	0.5616253

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000654	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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