Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 656)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0750572	0.1233929	0.5495261
Weighted median	23	0.0543055	0.0568266	0.3392564
Inverse variance weighted	23	0.0253575	0.0473344	0.5921588
Simple mode	23	0.2055800	0.1107535	0.0768701
Weighted mode	23	0.0560438	0.0680995	0.4193572

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.08948	21	0.0573400
Inverse variance weighted	32.38208	22	0.0711113

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003052	0.0069747	0.6661544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009941	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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