Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 655)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0085635	0.0998212	0.9324470
Weighted median	23	0.0024907	0.0544622	0.9635236
Inverse variance weighted	23	0.0135883	0.0390158	0.7276333
Simple mode	23	0.0667941	0.0879320	0.4555502
Weighted mode	23	-0.0027356	0.0594964	0.9637416

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.27668	21	0.6942037
Inverse variance weighted	17.33481	22	0.7446188

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013603	0.0056424	0.8118211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000529	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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