Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 654)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0701348	0.1477392	0.6398860
Weighted median	23	-0.0674990	0.0570029	0.2363605
Inverse variance weighted	23	-0.0137704	0.0566474	0.8079351
Simple mode	23	0.0093158	0.0882576	0.9168941
Weighted mode	23	-0.0533109	0.0641188	0.4146591

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.00211	21	0.0012770
Inverse variance weighted	46.37844	22	0.0017673

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034613	0.0083509	0.6827232

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001409	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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