Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 653)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0707868	0.0998199	0.4860336
Weighted median	23	-0.0408146	0.0554698	0.4618539
Inverse variance weighted	23	-0.0061071	0.0390155	0.8756158
Simple mode	23	0.1122874	0.1136217	0.3337720
Weighted mode	23	0.1096726	0.0896649	0.2342183

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.24885	21	0.6332067
Inverse variance weighted	18.74441	22	0.6610536

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003972	0.0056423	0.4891882

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8