Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 652)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0520147	0.0998205	0.6077612
Weighted median	23	-0.0187035	0.0564538	0.7404136
Inverse variance weighted	23	-0.0144706	0.0390157	0.7107177
Simple mode	23	-0.0531713	0.0904898	0.5627875
Weighted mode	23	-0.0365121	0.0671346	0.5920044

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.18260	21	0.6999796
Inverse variance weighted	17.34957	22	0.7437808

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023056	0.0056423	0.6869544

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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