Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 651)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1378973	0.0998201	0.1816609
Weighted median	23	-0.0284822	0.0578558	0.6225105
Inverse variance weighted	23	-0.0267727	0.0390153	0.4925811
Simple mode	23	-0.1813013	0.1184897	0.1402447
Weighted mode	23	-0.1298366	0.0817238	0.1263918

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.46333	21	0.6195248
Inverse variance weighted	21.67544	22	0.4793978

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0101124	0.0056423	0.0875156

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006711	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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